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[32] This restrictive procedure reduces stomach capacity, limits food intake, and alters gut hormone productionparticularly ghrelin, the 'hunger hormone'

Ether lipids promote susceptibility to ferroptosis, particularly when containing a polyunsaturated fatty acyl (PUFA) chain 51,52

Also, many patients discontinued treatment before the end of the study period

This article should not be interpreted as clinical guidance for microdosing practices but should instead serve as a resource for clinicians who may consider microdosing tirzepatide- MDP for patients who would benefit from this alternative dosing strategy Microdosing tirzepatide is not endorsed by the manufacturer or approved by any regulatory agency While microdosing is a reasonable approach to individualizing care the lack of supporting data should give pause to inexperienced users, considering the possible medical and legal implications and liability for dosing errors or adverse events experienced by patients

Reimbursement remains a sticking point